Stem cells in urine easy to isolate and have potential for numerous therapies

Public release date: 31-Jul-2013
[ | E-mail | Share ]

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center

WINSTON-SALEM, N.C. July 31, 2013 Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types.

"These cells can be obtained through a simple, non-invasive low-cost approach that avoids surgical procedures," said Yuanyuan Zhang, M.D., Ph.D., assistant professor of regenerative medicine and senior researcher on the project.

Reporting online in the journal Stem Cells, the team successfully directed stem cells from urine to become bladder-type cells, such as smooth muscle and urothelial, the cells that line the bladder. But the urine-derived cells could also form bone, cartilage, fat, skeletal muscle, nerve, and endothelial cells, which line blood vessels. The multipotency of the cells suggests their use in a variety of therapies.

"These stem cells represent virtually a limitless supply of autologous cells for treating not only urology-related conditions such as kidney disease, urinary incontinence and erectile dysfunction, but could be used in other fields as well," said Zhang. "They could also potentially be used to engineer replacement bladders, urine tubes and other urologic organs."

Being able to use a patient's own stem cells for therapy is considered advantageous because they do not induce immune responses or rejection. However, because tissue-specific cells are a very small subpopulation of cells, they can be difficult to isolate from organs and tissues.

Zhang's team first identified the cells, which are a small subset of the many cells found in urine, in 2006. The current research builds on earlier studies by confirming the multipotency of the cells. In addition, the research found that unlike iPS cells or embryonic stem cells, the urine derived-stem cells do not form tumors when implanted in the body, indicating they may be safe for use in patients.

The research involved obtaining urine samples from 17 healthy individuals ranging in age from five to 75 years. Isolating the cells from urine involves minimal processing, according to the authors. Next, they evaluated the cells' ability to become multiple cell types.

Importantly, the cells differentiated into the three tissue layers (endoderm, ectoderm and mesoderm) that are a hallmark of true stem cells and also differentiated into the specific cell types mentioned earlier.

Next, the researchers placed cells that had been differentiated into smooth muscle and urothelial cells onto scaffolds made of pig intestine. When implanted in mice for one month, the cells formed multi-layer, tissue-like structures.

The urine-derived stem cells have markers of mesenchymal cells, which are adult stem cells from connective tissue such as bone marrow. They also have markers for pericytes, a subset of mesenchymal cells found in small blood vessels.

Where do the cells come from? Researchers suspect that the cells originate from the upper urinary tract, including the kidney. Female study participants who had received kidney transplants from male donors were found to have the y chromosome in their urine-derived stem cells, suggesting the kidney as the source of the cells.

"Identifying the origins of the cells will lead to a better understanding of the biology of this multipotent population of mesenchymal cells within the urinary tract system," said Zhang.

###

Co-researchers were Shantaram Bharadwaj, Ph.D., Guihua Liu, M.D., Ph.D., Yingai Shi, M.D., Ph.D., Rongpei Wu, M.D., Ph.D., Bin Yang, M.D., Ph.D., Anthony Atala, M.D., and Jan Rohozinski, Ph.D ., Wake Forest Baptist; Tong-chan He, M.D., Ph.D., the University of Chicago Medical Center; Yuxin Fan, M.D., Ph.D., and Xinyan Lu, M.D., Baylor College of Medicine; Xiaobo Zhou, Ph.D., the Methodist Hospital Research Institute; and Hong Liu, Ph.D., University of Oklahoma.

Media contacts: Karen Richardson, krchrdsn@wakehealth.edu, 336-716-4453; Media Relations Office, 336-716-4587.

Wake Forest Baptist Medical Center is a fully integrated academic medical center located in Winston-Salem, N.C. The institution comprises Wake Forest School of Medicine, a leading center for medical education and research; Wake Forest Baptist Health, the integrated clinical structure that includes nationally ranked Brenner Children's Hospital; Wake Forest Innovations, which promotes the commercialization of research discoveries and operates Wake Forest Innovation Quarter, an urban research and technology park; plus a network of affiliated community hospitals, physician practices, outpatient services and other medical facilities. Wake Forest Baptist clinical programs and the School of Medicine are regularly ranked among the best in the country by U.S. News & World Report.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 31-Jul-2013
[ | E-mail | Share ]

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center

WINSTON-SALEM, N.C. July 31, 2013 Could harvesting stem cells for therapy one day be as simple as asking patients for a urine sample? Researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine and colleagues have identified stem cells in urine that can be directed to become multiple cell types.

"These cells can be obtained through a simple, non-invasive low-cost approach that avoids surgical procedures," said Yuanyuan Zhang, M.D., Ph.D., assistant professor of regenerative medicine and senior researcher on the project.

Reporting online in the journal Stem Cells, the team successfully directed stem cells from urine to become bladder-type cells, such as smooth muscle and urothelial, the cells that line the bladder. But the urine-derived cells could also form bone, cartilage, fat, skeletal muscle, nerve, and endothelial cells, which line blood vessels. The multipotency of the cells suggests their use in a variety of therapies.

"These stem cells represent virtually a limitless supply of autologous cells for treating not only urology-related conditions such as kidney disease, urinary incontinence and erectile dysfunction, but could be used in other fields as well," said Zhang. "They could also potentially be used to engineer replacement bladders, urine tubes and other urologic organs."

Being able to use a patient's own stem cells for therapy is considered advantageous because they do not induce immune responses or rejection. However, because tissue-specific cells are a very small subpopulation of cells, they can be difficult to isolate from organs and tissues.

Zhang's team first identified the cells, which are a small subset of the many cells found in urine, in 2006. The current research builds on earlier studies by confirming the multipotency of the cells. In addition, the research found that unlike iPS cells or embryonic stem cells, the urine derived-stem cells do not form tumors when implanted in the body, indicating they may be safe for use in patients.

The research involved obtaining urine samples from 17 healthy individuals ranging in age from five to 75 years. Isolating the cells from urine involves minimal processing, according to the authors. Next, they evaluated the cells' ability to become multiple cell types.

Importantly, the cells differentiated into the three tissue layers (endoderm, ectoderm and mesoderm) that are a hallmark of true stem cells and also differentiated into the specific cell types mentioned earlier.

Next, the researchers placed cells that had been differentiated into smooth muscle and urothelial cells onto scaffolds made of pig intestine. When implanted in mice for one month, the cells formed multi-layer, tissue-like structures.

The urine-derived stem cells have markers of mesenchymal cells, which are adult stem cells from connective tissue such as bone marrow. They also have markers for pericytes, a subset of mesenchymal cells found in small blood vessels.

Where do the cells come from? Researchers suspect that the cells originate from the upper urinary tract, including the kidney. Female study participants who had received kidney transplants from male donors were found to have the y chromosome in their urine-derived stem cells, suggesting the kidney as the source of the cells.

"Identifying the origins of the cells will lead to a better understanding of the biology of this multipotent population of mesenchymal cells within the urinary tract system," said Zhang.

###

Co-researchers were Shantaram Bharadwaj, Ph.D., Guihua Liu, M.D., Ph.D., Yingai Shi, M.D., Ph.D., Rongpei Wu, M.D., Ph.D., Bin Yang, M.D., Ph.D., Anthony Atala, M.D., and Jan Rohozinski, Ph.D ., Wake Forest Baptist; Tong-chan He, M.D., Ph.D., the University of Chicago Medical Center; Yuxin Fan, M.D., Ph.D., and Xinyan Lu, M.D., Baylor College of Medicine; Xiaobo Zhou, Ph.D., the Methodist Hospital Research Institute; and Hong Liu, Ph.D., University of Oklahoma.

Media contacts: Karen Richardson, krchrdsn@wakehealth.edu, 336-716-4453; Media Relations Office, 336-716-4587.

Wake Forest Baptist Medical Center is a fully integrated academic medical center located in Winston-Salem, N.C. The institution comprises Wake Forest School of Medicine, a leading center for medical education and research; Wake Forest Baptist Health, the integrated clinical structure that includes nationally ranked Brenner Children's Hospital; Wake Forest Innovations, which promotes the commercialization of research discoveries and operates Wake Forest Innovation Quarter, an urban research and technology park; plus a network of affiliated community hospitals, physician practices, outpatient services and other medical facilities. Wake Forest Baptist clinical programs and the School of Medicine are regularly ranked among the best in the country by U.S. News & World Report.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-07/wfbm-sci073013.php

terminator salvation jarhead montrose marshawn lynch earthquake bay area deron williams clear channel

Special Software Lets the NSA Collect "Nearly Everything" You Do Online

Just when you thought the scale of the NSA's surveillance programs couldn't get more superlative, new details about a special software suite show that analysts can access "nearly everything a typical user does on the internet." If it uses HTTP, the NSA can get it.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/9olAMY70nME/special-software-lets-the-nsa-collect-nearly-everythin-975562441

amanda knox Danny Brown The Following Real Madrid Neverwinter George Jones Farrah Abraham Tape

'Housewives' stars free on bond, travel restricted

NEWARK, N.J. (AP) ? A star of "The Real Housewives of New Jersey" and her husband were each released on $500,000 bond after making initial court appearances Tuesday on federal fraud charges.

Teresa Giudice and her husband, Giuseppe "Joe" Giudice, were ordered to surrender their passports and restrict their travels to New Jersey and New York. Joe Giudice, an Italian citizen, could be deported if convicted.

The Giudices, who rose to celebrity status by showcasing their lavish lifestyle on the Bravo reality TV show, were indicted Monday on bank and bankruptcy fraud charges, among other counts.

Joe Giudice is also charged with failing to file tax returns from 2004 to 2008, when he is alleged to have earned nearly $1 million.

The couple is accused of exaggerating their income while applying for loans before their show debuted in 2009, then hiding their fortunes in a bankruptcy filing after their first season aired.

The couple did not enter pleas during the brief appearance in a courtroom packed with media and spectators. Their arraignment was set for Aug. 14. Their attorneys said both will plead not guilty.

"The investigation went on for a pretty long time and we are confident we have enough evidence to convict the defendants beyond a reasonable doubt," U.S. Attorney Paul Fishman said after the proceeding.

Both face hundreds of years in prison and millions of dollars in fines if convicted, but federal sentencing guidelines would greatly reduce the penalties, Fishman said.

Teresa Giudice's attorney, Henry Klingeman, said he believes the government is prosecuting the couple because of their celebrity.

The couple filed for bankruptcy in 2009, claiming they owed $11 million, including $2.2 million in mortgages, $13,000 to Neiman Marcus and Nordstrom, and nearly $12,000 to a fertility clinic.

Joe Giudice also is facing charges in Passaic County that he used his brother's identity to obtain a driver's license, presenting his marriage and birth certificates. He rejected a plea deal in April through his lawyer, Miles Feinstein.

"In Passaic County, where I represent him, I feel that because of his celebrity status he's being treated differently than others are for the same offense," said Feinstein, who did not comment on the federal case.

Teresa Giudice has parlayed her fame into cookbooks, a line of ready-made bellinis and "Skinny Italian," a specialty food line.

On the show, she is known for her expensive tastes and combative relationship with her brother and sister-in-law. But Klingeman noted that the show helps support the couple and their four children.

"While it's called reality TV," Klingeman said, "I'm not sure everything you see on the show is real."

Source: http://news.yahoo.com/housewives-stars-free-bond-travel-restricted-180920944.html

creutzfeldt jakob disease the lone ranger mad cow pennsylvania primary jerome simpson hand sanitizer obama on jimmy fallon

Samsung Galaxy Tab 3 (line) Review

{content}';

var google_adnum = 0;
function google_ad_request_done(google_ads) {
for(i = 0; i Ads by Google";
var content = "";

if (ad.type == "flash") {
content += '';
} else if (ad.type == "image") {
content += ''; } else if (ad.type == "html") { content += ad.snippet; } else { content += '' + ad.line1 + '
' + '' + ad.line2 + '?' + ad.line3 + '
' + '' + ad.visible_url + ''; } content = ad_template.replace("{title}",title).replace("{content}",content); var pos = i*3 + (i+2); $('#posts .postcontainer:eq(' + pos + ')').after(content); } if (google_ads[0].bidtype == "CPC") google_adnum = google_adnum + google_ads.length; } google_ad_client = "ca-pub-8460099860738313"; google_ad_channel = '5062690591'; /*google_ad_slot = '8040314026';*/ google_ad_output = 'js'; google_max_num_ads = '10'; google_ad_type = 'text'; google_image_size = '728x90'; google_feedback = 'on'; google_skip = google_adnum; //]]>

Source: http://forums.androidcentral.com/samsung-galaxy-tab-3/301143-samsung-galaxy-tab-3-line-review-new-post.html

Wimbledon 2013 Gena Charmaine Avery dwight howard mariah carey djokovic djokovic josh smith

JFK Assassination Movie: First Look at Zac Efron in Parkland

Source: http://www.thehollywoodgossip.com/2013/07/jfk-assassination-movie-first-look-at-zac-efron-in-parkland/

first day of summer Abby Wambach Xcel Energy Super Moon 2013 miami heat Kim Kardashian Baby Lil Snupe

Adventures with Jaap: Home Sweet Home

Jaap and I spent the first two weeks of May visiting family and friends in NY. It's always good to come home and this time we got to celebrate the pregnancy (complete with a surprise baby shower!) with family and friends.?

No trip to NY would be complete without an evening with Shannon, my best friend, and our NY buddies. After a night out on the Lower East Side we enjoyed a delicious breakfast at Floridita. If you want the best coffee in NYC, go to Floridita and order a cafe con leche. It's up on the West side on 125th St and Riverside Drive.?

What was planned as a casual lunch with my aunts turned out to be a surprise baby shower complete with Muppets! Thanks to my amazing sister and mother for organizing the day. It was such a great surprise to see our closest famiy and friends there. What a day. We got so much great stuff for the baby and Jaap was able to celebrate in Muppet style. We felt very loved. Now we just wait for the little Jansen-Pardo to arrive!

Source: http://adventureswithjaap.blogspot.com/2013/07/home-sweet-home.html

jionni lavalle earthquake san francisco donald payne elizabeth berkley lenny dykstra mlb 12 the show sabu

Loeb's Third Point opens stake in CF Industries: letter

NEW YORK (Reuters) - Daniel Loeb's hedge fund Third Point initiated a new position in nitrogen fertilizer manufacturer CF industries during the second quarter, according to a quarterly investor note.

"CF currently trades at an unwarranted discount to fertilizer and commodity chemical peers," Loeb said in the letter, dated July 29. "We believe its structural cash flow generation strength is misunderstood and that management should deliver a much larger dividend to its shareholders."

Loeb said that CF's "access to low-cost North American natural gas - the primary input in nitrogen fertilizer production - gives the company a structural, sustainable margin capture relative to global peers with higher input costs."

(Reporting by Katya Wachtel; Editing by Gary Hill)

Source: http://news.yahoo.com/loebs-third-point-opens-stake-cf-industries-letter-193209325.html

survivor titus young Kristen Wiig Leila Fowler Seth Meyers mothers day Mothers Day Cards

Storms across Central Florida cause flooding, downed trees

Strong storms pushed across Central Florida Sunday evening leaving behind downed trees and flooded streets.

Places like U.S. Highway 17-92 near the Winter Park Village took on so much water that it created dangerous conditions for some drivers.

Click to read more.

Source: http://www.nbcnews.com/id/52607945/ns/local_news-orlando_fl/

drake eva longoria April Macie nicki minaj celebrity apprentice Jodi Arias Trial Live Bay to Breakers

Top Credit Improvement Tips To Get You Going | - JGVFinance

Have you been suffering from poor credit for years? Many people have credit scores that are getting worse. Fortunately, a number of methods for improving such ratings do exist, and you can begin using them right away by reading these helpful hints.

Try to keep a balance of less than 50% of your available credit on all of your cards. When balances are over 50%, your credit rating goes down significantly, so try to either spread out your debt or, ideally, pay off your credit cards.

Work with the companies to whom you owe money to get your debt back under control. This will help you stabilize your situation and start working towards a better financial situation. Contact your credit card company and request to change your scheduled due date or interest rate.

Credit Counseling

Consumers should carefully research credit counseling agencies before choosing one with which to work. You will find some counselors that truly want to help you fix your credit situation, while others may have different motives. Some are not legitimate. Intelligent customers will make sure to determine the legitimacy of a credit counseling agency before acquiring their services.

Stay cautious and aware of scams online that can lead you to even bigger problems. A common scam involves teaching you how to make a completely new, albeit fraudulent, credit file. This is illegal and you will eventually be caught. The end result of getting caught during the crime could be expensive legal fees and a possibility of time behind bars.

Call and request lower limits on your cards from the credit card companies. Doing this keeps you from overtaxing yourself. It also shows the lending company that you are responsible.

You should look over all negative reports thoroughly when attempting to fix your credit. Errors are not infrequent in credit reports. If you can prove the credit bureau is in the wrong, they should correct the reported error or remove it entirely.

Find and challenge errors on your credit report using the dispute process offered by each credit reporting agency. Draft a letter to reporting agencies disputing negative entries and also submit any available documentation. Send your dispute package with a return receipt request so that you have proof that it was received by the agency.

It is crucial that you review credit card bills on a monthly basis to check for errors. If this is the case, you need to call the company right away to avoid them from reporting it to credit reporting agencies.

Any time you establish any payment plan with any creditor, make sure you get it in writing. This is a great way to have documentation of the plan if the creditor changes their mind or the company ownership gets changed. As soon as you get it paid off, have that in writing so you are able to inform the credit reporting agencies.

You may want to argue against the reports, but potential lenders will not take your statements into consideration. The action of making a statement about your negative history will work against you as it highlight your mistakes rather than downplaying them.

Collection Agencies

Some of the worst stress you experience with bad credit is caused by debt collection agencies. A consumer has the legal option of using cease and desist letters to dissuade collection agencies, but it is vital to keep in mind that C&D letters only stop harassment. This doesn?t let the customer off the hook for the debt, it merely stops the threatening calls.

Be careful of paying for a service or a lawyer that advertises quick or instant credit score improvement, many of them are dishonest. A lot of people are having difficulty with their credit, and there are lawyers that try to exploit these people with illegal and ineffective credit restoration services. Do your homework and check out any attorney before you hire one to help with credit improvement.

Part of a nasty credit crunch is having multiple debts that you do not have the money to pay. Try to make sure that you find a little bit of money in your budget for all the creditors you owe payments to. Making the minimum payments will, at least, avoid ending up with collection agencies.

You need a plan and schedule when it comes to paying off your debt. These accounts will still appear on a credit report, but they will be earmarked as paid.

If a poor credit rating has left you feeling discouraged, turn your situation around by applying the guidelines you have just read. They can stop your credit from falling any further, and get you back on the road to recovery.

Author Lindsey Mooomsy is interested to reveal and ask you all man to learn more about exciting topics on Ultrasound Technician Salary Range
with more guide and revealing info on small black coffee table?
http://www.datarecoveryservices-online.com/

Source: http://www.jgvfinance.com/credit/top-credit-improvement-tips-to-get-you-going/

Newton virginia tech shooting China glock 121212 Concert Columbine shooting Ryan Lanza Facebook

Packaging labeled 'iPhone 5C' shows up in China, leads to more color iPhone speculation

? Home | Apple Stock | Tracked Sites | TechNN | | E-Mail | Sherlock Plugin Close Left Panel | Login | Subscribe to MacSurfer's Headline News Poll | Most Popular | Talking Heads | A Year Ago Today | Sunday, July 28, 2013 Checked 12:55 PM; Last Updated 12:50 PM CDT; 17:50 GMT
?
Subscriptions Benefits Include: ? Custom Newspages ? Keyword-Built Page ? Timestamp Options ? Choice of RSS Feeds ? Headline Discussions ? MORE ...	This weekend's MU PROMO offers 50% savings on Sparkbox 1.2. "Sparkbox is an intuitive app that not only organizes your photo collection but makes it searchable, giving you smooth, simplified access to your sources of inspiration! Built from the ground up with designers in mind, Sparkbox lets you tag and sort your photos for later use with its seamless, color-focused search engine. Finally, the process of collecting images that match your desired color palette is fast and stress-free! Now with full Dribble integration, Sparkbox is the photography tool that organizes and inspires!" Google's Hugo Barra admits Android tablets have been lacking. Will the next iteration make a dent in the iPad's hegemony? Vote for the results in the left column below or go straight to the results here. Weekend Highlights: At Fortune, Philip Elmer-Dewitt notes yesterday's AppleInsider piece on Samsung and notes all the tech journalists who mis-reported the story; AppleInsider and iMore report on photos of iPhone 4C boxes which have surfaced in China; Brett Terpstra analyzes some of the implications of tagging in OS X Mavericks; at eXtensions, Graham K. Rogers reviews Layrs, an interesting free iPhone App for editing laters in images; Daniel Eran Dilger at AppleInsider completes his series of three articles on the importance of iOS in the car with today's Editorial on the strategic importance of iOS in the Car; ...And Daniel E.D. is back for a second time Saturday on AppleInsider, this time questioning the notion that Samsung has dethroned Apple as smartphone profit leader; The Macalope takes three pundits to task for believing rumors, ignoring facts, and misconstruing Apple's business model; Fortune follows up on smart phone growth in China; at the Guardian, Charles Arthur casts doubt on the veracity of developer email addresses shown in documentation of the Apple Developer 'supposed' site hack; 9 to 5 Mac offers up help on the complications possible dealing with an Apple ID; Hot off the heels of Apple's Q3 earnings comes word iPhone market share has dopped to a three-year low; Samsung reaping the victory, overtaking Apple's four-year reign as most profitable phone maker in the world; reports aplenty in our Apple/Macintosh, and General Interest sections; meanwhile Daniel Eran Dilger at AppleInsider continues with the second part in his investigation into Apple's aggressive iOS in the Car future; phishing scam attempting to fool Apple developers in light of recent outage. WEEKEND BLOWOUT: Every NEW or RENEWING paid subscriber receives 2 YEARS FREE.
	Welcome to MacSurfer's Headline News! Is this the headline you are looking for? Sun Jul 28 "Packaging labeled 'iPhone 5C' shows up in China, leads to more color iPhone speculation" iMore 9:02 AM News "Apple Developer Portal Back Online, Partially"?PC Magazine?7/27 "Apple's developer site stirs back to life after downtime: After more than a week of downtime, Apple's bringing back some major parts of its developer site and connected services."?CNET News?7/27 "Apple restores key parts of dev site after attack: Eight days after taking site offline, resurrects important sections, including dev centers and downloads"?Computerworld?7/27 "Apple Re-Opens Developer Center After Security-Related Outage"?HotHardware?7/27 "Apple Developer site hack: doubts cast on Turkish hacker's claims/Guardian investigation raises questions over claims by Turkish researcher that he hacked into Apple's Developer portal"?The Guardian?7/27 "Apple Developer Center comes back online (partially) after massive outage"?ZDNet?7/26 "Access to Apple developer site partially restored"?Reuters?7/26 "Apple's developer site stirs back to life after downtime"?CNET News?7/26 "Apple's Developer Center is back after over a week offline"?9 to 5 Mac?7/26 "Apple's Dev Center back online after 8-day downtime"?AppleInsider?7/26 "Apple Relaunches Developer Software Downloads, Dev Centers for iOS and Mac, More"?The Mac Observer?7/26 "Apple Developer Website, Certificates, Identifiers, Profiles, Downloads Back Online"?FairerPlatform?7/26 "Apple Developer Center outage exploited with new phishing scam"?TechnologyTell?7/26 "OS X Mavericks Developer Preview: Safari Power Saver Saves Your Battery by Pausing Flash"?MacTrast?7/26 AppleCare/Troubleshooting "Q&A: MacFixIt Answers/Questions answered in this week's Q&A include OS X not prompting for how to handle home folders when an account is removed, and more."?CNET Reviews?7/26 "Can FileVault be bypassed with OS X password reset routines? Given Apple-supplied password reset tools, you may have concerns about the possibility of these being used to override a FileVault-protected volume."?CNET Reviews?7/26 Reviews/How-To/Tips "Review: SushiReader a simple app for RSS feeds"?Macworld?9:38 AM "Suitcase Fusion 5, a new version of font management"?IT.Enquirer?7:30 AM "Logic Pro X review: Powerful new features & a simplified UI with no compromises for pros"?9 to 5 Mac?7/26 "Softpress Freeway Pro 6 review - Comprehensive web design solution for OS X"?Macworld UK?7/26 "Mac Gems: Properly tag your videos with IDentify"?Macworld?7/26 "MacMost Now 896: Quickly Locking Your Mac"?MacMost?7/26 "Delete Files And Folders Selectively, Without Sending Them To The Trash [OS X Tips]?Cult of Mac?7/26 "A Free Password Manager App And Secure Wallet For Macs That's Not Quite A Bargain"?Mac 360?7/26 "How To Protect Your Mac's Online Privacy With A Cookie"?TeraTalks?7/26 "How To Make Your Mac More Secure And Private"?Mac 360?7/26 "Bored With iPhoto's Photo Enhancement Options? Add Fotor To Your Mac For Free"?NoodleMac?7/26 "The Easiest Way To Be A Mac Power User"?Mac 360?7/26 Op/Ed Press Releases "The Best iDVD Alternative DVD Photo Slideshow for Mac Released"?prMac?7/27 "PrivacyScan 1.3 Adds New Privacy Features, Discounted Pricing, Free Trial Available"?SecureMac?7/26 "Apple creates academic advisory board to oversee its Supplier Responsibility program"?TUAW?7/27 "Apple Scores Harris Poll Hat Trick"?AllThingsD?7/26 "We (Still) Love Apple! Americans Vote Tech Giant 'Brand Of The Year' Across Three Categories"?Digital Trends?7/26 "Apple is America's computer, tablet, and smartphone brand of the year"?VentureBeat?7/26 "Apple Named 'Brand of the Year' for PCs, Mobile"?PC Magazine?7/26 "Why consumers love Apple: Harris Interactive's annual poll names Apple computer, tablet and mobile 'Brand of the Year'"?Macworld UK?7/26 "Apple Dominates Consumer Brands Poll: Apple wins brand of the year from U.S. consumers in Harris Interactive poll's smartphone, tablet and PC categories."?InformationWeek?7/26 "Apple wins Harris Interactive Brand of the Year in three categories"?TUAW?7/26 "Apple wins top spots for 'Brand of the Year' in Harris poll"?CNET News?7/26 "Apple Pulls Hat Trick, Taking Computer, Tablet, and Mobile Phone 'Brand of the Year' Harris Poll EquiTrend Categories"?MacPrices?7/26 "LA Unified School District will give each of its 640,000 kids iPads by the end of next year"?9 to 5 Mac?7/26 "All of LA's 640,000 schoolkids will get free iPads by the end of 2014"?The Verge?7/26 "L.A. Unified School District Wants iPads for All 640,000 Students"?AllThingsD?7/26 "640,000 LA Students Will Get Free iPads by 2014: $30 million deal with Apple will get 31,000 iPads in classrooms this year, all students covered by 2014"?NBC South Florida?7/26 "Los Angeles Schoolkids Get Free iPads by Late 2014"?LAPTOP Magazine?7/26 "Apple taps academics to advise Supplier Responsibility program"?AppleInsider?7/26 "Galaxy S4 success helps Samsung to ?4.5bn profits, surpasses Apple in smartphone market"?V3?7/26 "Samsung and Apple Successfully Fend Off Low-Cost Smartphone Vendors for Another Quarter Declares ABI Research"?Business Wire?7/26 "Samsung and Apple successfully fend off low-cost smartphone vendors for another quarter, declares ABI Research"?DigiTimes?7/26 "Samsung Overtakes Apple But A Third Way Is Coming"?Forbes?7/26 "Samsung overtakes Apple in phone profits but others grow sales even more"?GigaOM?7/26 "App Puts the Bible in 100 Million Palms"?New York Times [Free/Paid Registration Required]?7/26 "How Samsung Pipped Apple In Chinese Mkt"?RTRS?7/26 "Apple IPhone Share Shrinks as China's Huawei to ZTE Lure Users"?Bloomberg?7/26 "Are cheap, unofficial non-Apple iPhone chargers safe? Following two electrocutions, Apple updates Chinese site with detailed advice on use of official iPad, iPhone chargers"?Macworld UK?7/26 "Apple's shock treatment: An authentic charger-spotting guide"?The Register?7/26 "Steve Jobs' Wife Has Invested In New Media Startup Called Ozy Media"?Business Insider?7/26 "Steve Jobs' Widow Invests in Former MSNBC Anchor's Media Site"?Mashable?7/26 "Laurene Powell Jobs Invests in Media Company Focused on Change"?The Mac Observer?7/26 "iPhone app catches would-be rapist in less than an hour"?Mirror Online UK?7/26 "Japanese Tourist Spots Now Have Camera Stands For iPhones"?Cult of Mac?7/26 Non-Apple News "Twitter comes under fire for what critics say is a lack of response to rape threats"?GigaOM?7/27 "Pinterest Adds New Features, Support For Do Not Track"?redOrbit?7/27 "Instagram users complain after being struck by mysterious 'smoothie hack'"?The Verge?7/27 "How 'Sword and Sworcery' became a global, cross-platform hit"?The Verge?7/27 "New Google Glass Patent Illustrates Customization Options"?Patent Bolt?7/26 "T-Mobile Eliminates Smartphone Down Payments In New Summer Deal"?Cult of Android?7/26 "Samsung's Profit Soars 50% on Solid Smartphone Sales"?WSJ.com [Paid Membership Required]?7/26 "Shipments of 15-inch notebooks decreasing, while 11-inch rise"?DigiTimes?7/26 Publications/Podcasts "9to5Mac Happy Hour Podcast: Virtual personal assistants and Chromecast"?9 to 5 Mac?7/26 "The GigaOM Show: Google v. Apple gets Chromecastical"?GigaOM?7/26 Deal Brothers Daily Deal: Save $25 on 5th Gen 32GB Apple iPod Touch, Free Shipping Reviews "Review: Polk Audio's Nue Era in-ear headphones"?9 to 5 Mac?12:47 PM "PCR's guide to mac peripherals"?PC Retail?7:52 AM "New Nexus 7 vs. iPad mini 2, bezel and letterbox"?Phones Review?7:49 AM "Review: Verus Apple iPhone 5 Leather Case Premium J Series"?Run Around Tech?8:12 AM "Mophie Juice Pack Reserve for iPhone 4/4S review"?ITProPortal?7:54 AM "Review: The iOttie Sprinkle Case for the iPhone 5"?Run Around Tech?7:48 AM "Fitbit Flex or Jawbone Up: Which is the better fitness companion for your wrist?"?GigaOM?7/27 "Nexus 7 2 gets its pixels up vs non-retina iPad mini"?Stabley Times?7/27 "Review: RHA M350 noise-isolating aluminum headphones + exclusive 20% discount code"?9 to 5 Mac?7/27 "The Week in iPad Cases: Oh boy!"?Macworld?7/27 "Best back to school iPad accessories for kids"?Phones Review?7/27 "Apple TV vs. Roku vs. Chromecast content options"?iDownload Blog?7/27 "Gadgets galore: Droid Maxx vs. Galaxy S4; Nexus 7 vs. iPad Mini"?CNET News?7/26 "iRig HD and Amplitube for iPad Review: IK Multimedia exceeds expectations yet again with a higher-resolution analog to digital audio converter for guitar, and a fantastic guitar-centric digital audio workstation and effects processor for iOS."?148Apps?7/26 "Sensu: Old World Art Brush for New World Touch Pads"?Bare Feats?7/26 "Aud 5 is a fine speaker/dock ? if you have a Lightning-equipped iDevice"?AppleDailyReport?7/26 iPad/iPhone/iPod touch Apps "Layrs: An Interesting Free iPhone App for Editing Layers in Images"?eXtensions?9:38 AM "Mac Gems: Noted a nicely-organized note-taking app"?Macworld?7/27 "iOS 7 preview: iOS in the Car hints at the future of iOS everywhere"?iMore?7/26 "Hands-on: Loom makes it increasingly tempting to ditch iPhoto and Photo Stream"?Macworld?7/26 "Getting fit with iOS: How your iPad and iPhone can help you shed pounds"?Macworld?7/26 "'Futuridium EP' Review - An Inventive Arcade SHMUP for the Hardcore"?Touch Arcade?7/26 "Chillaxian Review: Prepare for chillaxing while busting aliens in Chillaxian."?148Apps?7/26 "A Ride into the Mountains Review: As understated as just about every aspect of A Ride into the Mountains might be, everything comes together to craft a truly impressive experience."?148Apps?7/26 "Riptide GP2 Review: Riptide GP 2 improves on the fast-paced hydro jet racing action of its predecessor, adding new tracks, vehicles, and tricks for players to splash around with."?148Apps?7/26 "Vintage 80s Apple Ads Resurfacing on YouTube"?MacRumors?7/26 How-To/Tutorial "Watch TV on your Mac: the definitive guide/IN DEPTH The proper Apple TV isn't quite here yet, so why not watch TV on your existing Apple kit?"?TechRadar UK?7:54 AM "How to transfer photos from your iPhone to Mac/iOS/Mac OS X tips: Import photos from your iPhone or iPad to Mac with free software"?Macworld UK?7/26 "How to change the wallpaper on your iPad: Plus, where to find cool new wallpapers for your iPad"?Macworld UK?7/26 "How to get Flash on iPad: Best Flash apps to help you play Flash videos and games on your iPad"?Macworld UK?7/26 "How to finetune your mobile Safari browsing settings"?iDownload Blog?7/26 Tips "How to be an iOS ninja: Top 5 secret shortcuts for Siri, Mail, Safari, Calendar, keyboard, and more!"?iMore?7/27 "Games developer Kameleon Games announces Shark Attack 2 for iOS"?prMac?9:38 AM "Hipstamatic Oggl Updated With Photo Browsing And Sharing Enhancements"?AppAdvice?8:29 AM "HopStop Transit App Receives First Update Following Its Acquisition By Apple"?AppAdvice?7:37 AM "Amazon Mobile For iPad Gains Wish List Management, Product Sharing And More"?AppAdvice?7:48 AM "Squaregram 1.6.0 for iOS - Layouter for Instagram"?prMac?7:46 AM "ICON Releases Most Charming Dress Up App on Apple's App Store"?prMac?7:39 AM "inStatus 2.0 - A creative photo editing app bringing your photos to life"?prMac?7:44 AM "Sett Is A New Blogging Platform That Has Community At Its Heart"?TechCrunch?7/27 "New Grammar Game for iPad/iPhone for Kids to Learn Parts of Speech"?prMac?7/27 "SwagWarz 1.0 for iOS - Defeat Enemies Using Bling and Swag in 3D Shooter"?prMac?7/27 "Biber and Red Boots HD released for iOS - Interactive Children's App"?prMac?7/27 "Canon adds Apple AirPrint compatibility to newest Pixma Wireless All-in-One Printer"?AppleDailyReport?7/27 "Sensopia - Capture the Floor Plan of your House with MagicPlan"?Sensopia?7/27 "Mailbox Developer Orchestra To Shut Down Namesake To-Do App 2 Years After Launch"?AppAdvice?7/26 "iPhone Charging Connector Fits on Your Keychain: If you have easy access to a computer all day but don't want to carry your iPhone's charging cable around with you, the Kii might do the trick."?Techland?7/26 "Coming July 27: Gene Steinberg meets Peter Cohen, from The Loop and iMore, Kirk McElhearn, author of 'Take Control of Launchbar,' and Russell Chozick, of Flashback Data, this week on The Tech Night Owl LIVE!"?The Tech Night Owl LIVE?7/26 "'Cut the Rope' Gets 25 New Levels in Latest 'Cheese Box' Update"?Touch Arcade?7/26 "Shutterfly 2.0 Released for iPad"?iClarified?7/26 "Starbucks Selects Cyto's Puzzle Adventure For Its Pick of the Week, Offers Free Codes At 15,000 Locations"?148Apps?7/26 "Distro Issue 100: A look at our all-time favorite gadgets"?Engadget?7/26 "Steve Wozniak and Trip Hawkins Announced as Keynote Speakers at Apps World"?Business Wire?7/26 "Hot off the Press: Tekserve Releases Its First iOS FAQ, Alongside the 12th Edition of Their Mac FAQ"?Business Wire?7/26 "'Vjay' Goes FREE On iPhone (and iPad)"?RazorianFly?7/26 "Shutterfly For iPad 2.0 Features Product Ordering And Photo Filtering"?AppAdvice?7/26 "Sky takes on Apple and Netflix with super-cheap Now TV streaming box"?The Verge?7/26 "Channel 4 brings offline viewing to 4oD for Android and iOS"?Engadget?7/26 "Google Kills Google+ Local For iOS, App Now Pulled From iTunes App Store"?TechCrunch?7/26 "Google+ Local for iOS will be pulled on August 7th after being integrated into Google Maps"?The Next Web?7/26 "Google+ Local for iOS has one foot in the grave, will rest in peace August 7th"?Engadget?7/26 "4OD for iOS and Android gets offline viewing"?The Inquirer?7/26 "Gravity Evolved iOS App Release"?prMac?7/26 "Biber and Red Boots HD released for iOS - Interactive Children's App"?prMac?7/26 "BA Financial Calculator Pro 3.0 Emulates TI BA II Plus Professional Now"?prMac?7/26 "Awem launches Golden Trails 2 HD for iPad"?prMac?7/26 "Information of iPhone/iPad app Backyard - Release Info"?prMac?7/26 "Blast Virus - An Exciting Mobile Gaming App"?prMac?7/26 "Western Bar - Retro Classic LCD Game is now out"?prMac?7/26 "Mr Tiger the House Spider - Animoolz Interactive Children's Book"?prMac?7/26 "Memorability - Visual Storytelling App for iPad Released on App Store"?prMac?7/26 "Free Bible Trivia Word Game Now Available for iPad"?prMac?7/26 "Famous Movies for iPad: 20 Pixel-Art Puzzles for Every Cinema Fan"?prMac?7/26 "Dragons Rage 2 Hits The China App Store With A Fiery Chinese Edition"?prMac?7/26 "Available Now - Update your Facebook status with a PicUpdate picture"?prMac?7/26
?		?

Source: http://www.macsurfer.com/redirr.php?u=799786

jobs act greg mortenson jim marshall died 2013 toyota avalon the secret life of bees full moon aubrey o day

Hunter Mahan chooses his daughter's birth over golf

Hunter Mahan was leading the RBC Canadian Open golf tournament on Saturday. But then his wife went into labor. So, Hunter Mahan withdrew from the tournament.

By David Clark Scott,?Staff writer / July 27, 2013

Adios! Hunter Mahan waves after sinking a birdie putt on the 18th hole during the second round at the Canadian Open golf tournament in Oakville, Ontario. Mahan was leading the tournament on Saturday July 27, when he withdrew to attend the birth of his first child.

(AP Photo/The Canadian Press, Nathan Denette)

Enlarge

Golf is a sport that emphasizes integrity.

Skip to next paragraph David Clark Scott

Online Director

David Clark Scott leads a small team at CSMonitor.com that?s part Skunkworks, part tech-training, part journalism.

Recent posts

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; // google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

Subscribe Today to the Monitor

Click Here for your FREE 30 DAYS of
The Christian Science Monitor
Weekly Digital Edition

Players are expected to call penalties on themselves, even if no one is looking.

That's why it's fitting that Hunter Mahan ? who was leading the RBC Canadian Open after two rounds ?? withdrew to attend the birth of his daughter. Mahan did the right thing ? for himself, for golf, and for fathers everywhere.

That's not to say that it was an easy decision. Mahan hasn't won a PGA tournament this year. He finished in the top 10 in two recent big tournaments ? the US Open and the British Open Championship. Going into Saturday's third round, he was leading by two shots. And if he had won, Mahan would have pocketed a $1,008,000 winner's check.

How many new dad's would walk away from a $1 million pay day?

The baby wasn't due for a few weeks. But then his phone rang Saturday morning, while he was warming up on the practice range. His wife was in labor, her water had broken. He didn't hesitate. He politely left the tournament.

?I received exciting news a short time ago that my wife Kandi has gone into labor with our first child,? said Mahan. ?As a result, I have withdrawn from the RBC Canadian Open to return to Dallas. I would like to extend my very sincere gratitude and appreciation to RBC and the RBC Canadian Open.

"Kandi and I are thrilled about this addition to the Mahan family and we look forward to returning to the RBC Canadian Open in the coming years.?

Mahan is not the first golfer to face the challenge of fatherhood vs. work. As Yahoo Sports writer Jay Busbee wrote: "Back in 1999, Phil Mickelson famously wore a beeper during the U.S. Open. His daughter was born the day after Mickelson lost to Payne Stewart. More recently, Ross Fisher vowed to walk off the course at the 2009 British Open no matter what if he heard his wife was going into labor; he was just one stroke behind leader Tom Watson at the time."

And last fall, Chicago Bears cornerback Charles Tillman caused a stir when he suggested that the birth of his child would take precedent over showing up for his job. It sparked conversations on talk radio and in social media about work and family priorities. Tillman said:

"[Football will] always be second or third in my life. That was a great lesson learned, to teach me that family ? when I?m done playing football ? my family will always be there for me.?

As The Christian Science Monitor reported at the time, "Tillman's announcement drew criticism from some sports columnists and fans. Sport radio talk show starkly framed the question: "If you only work 16 days a year, should you miss one for the birth of your child?"

Tillman's daughter was eventually born on a Monday, saving the NFL player and fans from any further controversy.

But Mahan's daughter Zoe arrived on a work day. As a father, it's unlikely Mahan will regret the decision to leave the golf tournament. And there are probably more than a few dads ? who missed the birth of their first child ? who would now gladly give a $1 million to be there.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/iJzqogH2n1U/Hunter-Mahan-chooses-his-daughter-s-birth-over-golf

j.k. rowling j.k. rowling axl rose google earnings pat burrell hilary rosen grilled cheese

Microsoft's Windows NT turns 20

OSNews writes, Windows NT turned 20 years old today. From a 1998 story about NT, written by Mark Russinovich, "I'll take you on a short tour of NT's lineage, which leads back to Digital and its VMS OS. Most of NT's lead developers, including VMS's chief architect, came from Digital, and their background heavily influenced NT's development. After I talk about NT's roots, I'll discuss the more-than-coincidental similarities between NT and VMS, and how Digital reacted to NT's release."

Continue reading Microsoft's Windows NT turns 20 at OSNews

Source: http://technewstube.com/osnews/247736/microsofts-windows-nt-turns-20/

mississippi state chris carpenter chris carpenter dick cheney hcg drops reason rally mad hatter

Another Possible Bright Supernova Discovered In Spiral Galaxy M74

Want to stay on top of all the space news? Follow @universetoday on Twitter

One of the first photos of the new supernova (at tick marks) in the nearby galaxy M74 taken by the Italian Supernova Search Project. The object is located 93? east and 135? south of the galaxy?s center. Click to learn more about the search group. Credit: Fabio Martinelli

I love this galaxy. Not only does M74 display a near perfect spiral form but if this latest supernova is the third to ?go boom? in the galaxy in just 11 years. The new object, designated PSN J01364816+1545310, was discovered blazing near 12.4 magnitude by the?Lick Observatory Supernova Search?at Lick Observatory near San Jose, Calif. ?PSN? stands for ?possible supernova? and the long string of numbers give the object?s position in the sky using the celestial equivalents of latitude and longitude.

M74 is a classic spiral galaxy with arms that appear to unwind from a bright, star-packed nucleus. Located 32 million light years away in the constellation Pisces, M74 contains about 100 billion stars. The spiral arms are dotted with dense star clusters and pink clouds of fluorescing hydrogen gas. Credit: Jim Misti

The Lick search uses a fully robotic or automated 30-inch (76 cm) telescope dedicated to scanning the skies for new supernovae. It nailed M74?s latest exploding star on July 25. Two previous supernovae flared in the galaxy -?SN 2002ap?and?SN 2003gd?- and rose to 12th and 13th magnitude respectively before fading away into obscurity.

Size comparison of our Milky Way spiral galaxy with M74. The Milky Way measures about 100,000 light years across; M74 about 30,000. Credit: NASA (left) and Jim Misti

Three?s the charm as they say. A team of astronomers using a spectrograph at the Faulkes Telescope South at Siding Spring, Australia teased apart the supernova?s light and now know exactly what blew up. It appears our newcomer was originally a supergiant star at least 8 times as massive as the sun.?After a relatively brief lifetime measured in the millions of years, the supergiant gobbled up the last of its fuel. With the gas gauge on ?empty? and no new energy being produced in the core to hold back ?the force of gravity, the star imploded, sending a shockwave rocketing back in the opposite direction that tore it to bits.

When a massive star runs out of nuclear fuel in its core, the energy that has prevented the force of gravity from crushing it is gone. Gravity finally gains the upper hand causing the star to implode. A rebounding shock wave blows it to bits. Sometime a city-sized, dense stellar remnant called a neutron star remains after the blast. Credit: ESO

Called a Type II supernova explosion, the blast hurtles star stuff into space at up to 45,000 miles per second (70,000 km/sec). More amazing, a powerful supernova explosion can release as much energy as the sun during its entire 10 billion year lifetime. No wonder even small telescopes can spot these cataclysmic events from millions of light years away!

The galaxy M74, the 74th entry in 18th century astronomer Charles Messier?s catalog, is found about 1.5 degrees east-northeast of the star Eta Piscium just to the right of the small constellation Aries the Ram. The map shows the sky around 1 a.m. tomorrow morning facing east. Stellarium

As additional photos and measurements come in, ?amateur astronomers with 8-inch and larger telescopes will have no problem spying the supernova once the last quarter moon departs the vicinity. It?s located 93? (1.5?) ?east and 135? (more than 2?) southeast of the galaxy?s core. The map and photo will help you track it down.

This map measures only about 1/2-degree wide and shows the galaxy up close with the supernova marked SN. Selected star magnitudes from the AAVSO are shown to help you navigate to the object as well as estimate its brightness. North is up, west to the right. Map created with Chris Marriott?s SkyMap software

While M74 is relatively bright and appears spectacular in long-exposure photos, it looks like a large, dim featureless glow in smaller telescopes. Be patient and take your time to ?star hop? to the supernova using the more detailed map. Matter of fact, you may want to wait until Tuesday morning or later to look. That?s when the waning moon will finally depart the area. Let?s hope our new guest remains bright.

Good luck meeting the latest star to mark the end of its life with the biggest blowout of all. For more information and photos, stop by Dave Bishop?s Latest Supernovae site.

* This article was updated at 6:30 pm CDT on 7/28/13

?

About Bob King

I'm a long-time amateur astronomer and member of the American Association of Variable Star Observers (AAVSO). My observing passions include comets, variable stars, deep sky, and photographing sky events like conjunctions and northern lights.

Tagged as: M74, supernova

Source: http://www.universetoday.com/103766/another-possible-bright-supernova-discovered-in-spiral-galaxy-m74/

Columbine shooting Ryan Lanza Facebook Connecticut shooting Nancy Lanza school shootings Jenni Rivera Adam Lanza Facebook